Ranran Li | Signal Transduction Mechanisms | Best Researcher Award

Dr. Ranran Li | Signal Transduction Mechanisms | Best Researcher Award

Ranran Li , Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , China

Dr. Ranran Li is an associate researcher at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine in Shanghai, China. She earned her Ph.D. from the University Medical Center of Groningen, Netherlands, in 2015, before returning to Shanghai to focus on critical care medicine. Her research centers on sepsis-associated endothelial dysfunction and its underlying molecular mechanisms. Over the years, Dr. Li’s work has provided valuable insights into the role of metabolic disorders and post-translational modifications in regulating endothelial inflammation and coagulation during sepsis. She has published extensively in reputable journals and holds several patents. Her recent findings suggest potential therapeutic targets for the treatment of sepsis and related complications, including endothelial dysfunction and organ injury.

Publication Profile:

Scopus

Strengths for the Award:

Dr. Ranran Li is a distinguished researcher with notable expertise in the mechanisms of sepsis-associated endothelial dysfunction. Her work in identifying the role of metabolic disorders and post-translational modifications in sepsis has been pivotal in advancing the understanding of vascular inflammation and coagulation during critical illness. Her research has led to several high-impact publications and patents, showcasing her contributions to the field. Furthermore, Dr. Li’s interdisciplinary approach, combining metabolic biology, cell signaling, and translational medicine, has provided valuable therapeutic targets for the treatment of sepsis and endothelial dysfunction. Her collaborations with international experts enhance her work’s impact and broaden the scope of her research.

Areas for Improvements:

While Dr. Li’s research has been extensive and groundbreaking, future improvements could include increased collaborations with industry partners to accelerate the translation of her findings into clinical therapies. Expanding her professional network through international collaborations in other areas of critical care medicine could also provide new perspectives and avenues for innovation. Additionally, engaging in larger-scale clinical studies might help further validate her findings in human models.

Education

Dr. Ranran Li obtained her Ph.D. in Medical Sciences from the University Medical Center of Groningen, Netherlands, from 2011 to 2015. During her doctoral studies, she focused on the molecular mechanisms of sepsis and its impact on vascular endothelial dysfunction. Her Ph.D. research laid the foundation for her ongoing investigations into the pathophysiology of sepsis and endothelial injury. Following her Ph.D., she joined Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, in 2016 as an associate researcher in the Department of Critical Care Medicine. Here, Dr. Li furthered her research into sepsis, vascular inflammation, and metabolic disorders. She has developed an expertise in endothelial dysfunction and coagulation, specifically in the context of sepsis-induced organ injuries. Dr. Li’s comprehensive academic training, both in Europe and China, has significantly contributed to her innovative research work and international collaborations.

Experience:

Dr. Ranran Li has been serving as an associate researcher at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, since 2016. Prior to this, she earned her Ph.D. from the University Medical Center of Groningen in the Netherlands, where she focused on sepsis and endothelial dysfunction. In her current position, Dr. Li has worked extensively on understanding the mechanisms underlying sepsis-associated endothelial dysfunction, with a particular focus on metabolic disorders and post-translational modifications. Her work has provided critical insights into the role of fatty acid metabolism, insulin resistance, and histone modifications in regulating endothelial inflammation and coagulation activation in sepsis. Dr. Li’s research has led to multiple publications in high-impact journals and the filing of patents for innovative therapeutic approaches. She collaborates with leading researchers in the Netherlands and has contributed significantly to the understanding of vascular injury and its therapeutic targets in sepsis.

Research Focus:

Dr. Ranran Li’s research focuses on the molecular mechanisms of sepsis-associated endothelial dysfunction, with a particular emphasis on metabolic disorders and post-translational modifications. She has been exploring how fatty acid metabolism, glucose-lipid metabolism, and protein acetylation influence endothelial cells during sepsis, leading to organ injury. Her research has highlighted the role of metabolic shifts, including the activation of pathways like AMPK/PKA, in endothelial inflammation and coagulation activation. Dr. Li has also studied the role of histone modifications, including lactylation, in promoting endothelial ferroptosis and dysfunction during sepsis-induced lung injury. She has been pioneering the exploration of metabolic signaling pathways and their potential as therapeutic targets for managing sepsis-related endothelial damage. Her work aims to identify novel strategies to prevent or mitigate vascular injury in septic patients. Dr. Li’s findings have led to both patents and high-impact publications in critical care and translational medicine.

Publications Top Notes:

  1. Shiyuan He et al., Fatty acid synthesis promotes mtDNA release via ETS1-mediated oligomerization of VDAC1 facilitating endothelial dysfunction in sepsis-induced lung injury 🧬🫁 Cell Death and Differentiation, 2025
  2. Ranran Li et al., ATP-citrate lyase controls endothelial gluco-lipogenic metabolism and vascular inflammation in sepsis-associated organ injury 💉🧪 Cell Death and Disease, 2023
  3. Jie Liu et al., Designed microchannel-based lipid nanoparticles encapsulated siRNA targeting gasdermin D for sepsis management via pulmonary delivery 🧬💉 Nano Today, 2025
  4. Fangchen Gong et al., H3K14la drives endothelial dysfunction in sepsis-induced ARDS by promoting SLC40A1/transferrin-mediated ferroptosis 🧬🔥 MedComm, 2025
  5. Jiayin Cui et al., Herbal-based Xuebijing injection ameliorated vascular endothelial dysfunction via inhibiting ACLY/MYB/RIG-I axis in sepsis-associated lung injury 🌱💊 Phytomedicine, 2025
  6. Shasha Lu et al., GDF15 ameliorates sepsis-induced lung injury via AMPK-mediated inhibition of glycolysis in alveolar macrophage 💨🧪 Respiratory Research, 2024
  7. Rui Tian et al., Shenfu injection ameliorates endotoxemia-associated endothelial dysfunction and organ injury via inhibiting PI3K/Akt-mediated glycolysis 💉🫀 Journal of Ethnopharmacology, 2024
  8. Yupeng Zhao et al., H3K18 lactylation-mediated VCAM1 expression promotes gastric cancer progression and metastasis via AKT-mTOR-CXCL1 axis 🎗️🧬 Biochemical Pharmacology, 2024
  9. Rui Tian et al., Metformin ameliorates endotoxemia-induced endothelial pro-inflammatory responses via AMPK-dependent mediation of HDAC5 and KLF2 💊💉 BBA-Molecular basis of disease, 2019
  10. Lei Pei et al., MSCs-derived extracellular vesicles alleviate sepsis-associated liver dysfunction by inhibiting macrophage glycolysis-mediated inflammatory response 🧬🩸 International Immunopharmacology, 2024

Conclusion:

Dr. Ranran Li is highly deserving of the Best Researcher Award due to her outstanding contributions to understanding the molecular mechanisms underlying sepsis-related endothelial dysfunction. Her innovative research has not only provided deep insights into the pathophysiology of sepsis but has also uncovered potential therapeutic targets for treating this devastating condition. Her exceptional track record of high-quality publications, patents, and collaborative research, combined with her dedication to advancing critical care medicine, makes her an excellent candidate for this prestigious award.

Gonca Çelik | Developmental Cell Biology | Best Researcher Award

Assoc. Prof. Dr. Gonca Çelik | Developmental Cell Biology | Best Researcher Award

Assoc. Prof. Dr. Gonca Çelik , Karadeniz Technical University , Turkey

Assoc. Prof. Dr. Gonca Çelik, born on April 18, 1984, is a distinguished academic with an extensive background in chemistry, particularly in organic chemistry. She earned her bachelor’s degree in Chemistry Teaching from Karadeniz Technical University (KTU) in 2008. Later, she pursued a doctorate in Chemistry, specializing in Organic Chemistry, from KTU, completing her Ph.D. in 2017. With an h-index of 12, she has made significant contributions to scientific research, including 38 publications in SCI-Expanded indexed journals. Dr. Çelik is also recognized for her involvement in various research projects, particularly in enzyme inhibition, molecular docking studies, and the synthesis of bioactive compounds. Fluent in both Turkish and English, she actively collaborates internationally and has authored several impactful publications related to drug development and the synthesis of biologically active compounds, contributing to fields such as medicinal chemistry and biochemistry.

Publication Profile:

Scopus

Strengths for the Award:

Assoc. Prof. Dr. Gonca Çelik is a highly accomplished researcher with a strong background in organic chemistry, particularly in drug development and biological evaluations. Her significant contributions to the field are reflected in her 38 publications in SCI-Expanded indexed journals. She has demonstrated expertise in synthesizing bioactive compounds, investigating their biological activities, and applying molecular modeling techniques, including molecular docking and ADMET studies. Her work on the synthesis of flavonol derivatives, which are potential inhibitors of SARS-CoV-2, underscores her impact on global health research. Dr. Çelik has also been an active participant in multiple national and international research projects, including Tubitak-funded projects, focusing on enzyme inhibition and molecular modeling for disease treatment. Her leadership in scientific research, combined with a solid academic background, positions her as a valuable contributor to scientific advancements.

Areas for Improvement:

While Dr. Çelik’s research is impressive, there is room for greater visibility and dissemination of her findings to broader interdisciplinary audiences. Increased collaboration with researchers from other scientific fields, such as pharmacology and clinical medicine, could enhance the real-world application of her work, particularly in the development of drug therapies. Expanding her research focus to include more clinical trials or translational research could help bridge the gap between laboratory findings and practical medical applications. Additionally, increasing her involvement in scientific outreach or mentorship programs could further contribute to the development of the next generation of researchers in chemistry and pharmacology.

Education:

Dr. Gonca Çelik’s educational journey began with a Bachelor’s degree in Chemistry Teaching from Karadeniz Technical University (KTU) in 2008. She then pursued postgraduate studies, enrolling directly in the doctoral program in Chemistry at KTU, where she specialized in Organic Chemistry, completing her Ph.D. in 2017. Her doctoral research focused on developing bioactive organic compounds with potential therapeutic applications. Dr. Çelik has also gained international exposure during her Master’s studies, spending time at Clausthal University of Technology in Germany in 2014, which broadened her academic perspective and research experience. Over the years, her educational background and research expertise have provided a solid foundation for her ongoing contributions to the field of organic chemistry, particularly in medicinal chemistry, enzyme inhibition, and molecular docking studies. This strong academic base supports her continued success as an academic and researcher in the field of chemistry.

Experience:

Dr. Gonca Çelik’s academic and professional journey spans over a decade. She began her career as a Research Assistant at Karadeniz Technical University (KTU) in 2010, where she worked until 2017. During her time at KTU, she contributed to several research projects in the field of chemistry, including organic synthesis and biological evaluation of compounds. Her academic work has led her to publish multiple papers in international and national journals. In 2014, she expanded her research horizons by spending time as a Master Student at Clausthal University of Technology in Germany, further strengthening her academic profile. Dr. Çelik has also been involved in various Tubitak and KTU-supported research projects, particularly focusing on enzyme inhibition, molecular docking, and bioactive compound synthesis. She has held roles in multiple projects, such as the synthesis of flavonol derivatives for drug development and the study of antimicrobial and anticancer properties of organic compounds.

Research Focus:

Dr. Gonca Çelik’s primary research interests lie in the field of organic chemistry, with a particular focus on bioactive compound synthesis, enzyme inhibition, and molecular docking studies. Her research aims to discover and develop novel organic molecules with potential therapeutic applications, especially in drug development for diseases such as COVID-19. She has worked extensively on synthesizing flavonol derivatives and other bioactive compounds, investigating their enzyme inhibition efficiencies and biological activities. Dr. Çelik’s work in molecular modeling and computational studies (e.g., ADMET and molecular docking) complements her experimental research, helping to predict the behavior of synthesized compounds at the molecular level. Her research has contributed to the development of potential inhibitors for viruses and other diseases, highlighting her interdisciplinary approach that bridges chemistry and pharmacology. She has been involved in several national and international projects, contributing to the scientific community through her publications and innovative research efforts.

Publications Top Notes:

  1. Synthesis, Biological Evaluation and Molecular Docking Studies of Flavonol-3-O-β-D-glycoside as a Potential Inhibitor of SARS-CoV-2 Main Protease (3CLpro) in Drug Development for COVID-19 🧬💊
  2. Synthesis, structural, spectroscopic (NMR, FT-IR and UV–Vis), NLO, in silico (ADMET and molecular docking) and DFT investigations of a flavonol derivative 2-(4-chlorophenyl)-7-fluoro-3-hydroxy-4H-chromen-4-one 🧪🔬
  3. Antimicrobial, cytotoxic, antiviral effects, and spectroscopic characterization of metabolites produced by fusarium oxysporum yp9b 🦠💉
  4. Biological activity, and volatile and phenolic compounds from five Lamiaceae species 🌱🧴
  5. Synthesis, spectroscopic, and photophysicochemical behavior of Zn(II) and Mg(II) phthalocyanine–chalcone conjugates ⚙️🧑‍🔬
  6. New chalcone-3-O-glycoside derivatives: Synthesis and characterization 🧪🔬
  7. Synthesis and characterization of some new pyrazolines and their inhibitory potencies against carbonic anhydrases 🧫💥

Conclusion:

Dr. Gonca Çelik’s academic achievements, extensive publication record, and leadership in research make her a strong contender for the Best Researcher Award. Her work has made substantial contributions to drug development, specifically in the context of COVID-19 treatment, enzyme inhibition, and molecular modeling. With a solid foundation in chemistry and a forward-looking approach to interdisciplinary research, she continues to push the boundaries of scientific knowledge. Enhancing her outreach efforts and fostering collaborations with clinical researchers will further amplify the impact of her work on global health. Therefore, Dr. Çelik’s research excellence, combined with her potential for future advancements, makes her a deserving candidate for the Best Researcher Award.