Dr. Mengying Liu | Reproductive Biology | Best Researcher Award

Dr. Mengying Liu, Hangzhou Women’s Hospital, China

Dr. Mengying Liu is an accomplished biomedical researcher specializing in pregnancy-related diseases with a focus on epigenetic regulation. She earned her Ph.D. in Chemical Biology from Xiamen University and currently serves as an Assistant Researcher at Hangzhou Women’s Hospital. Her scientific journey is marked by a dedication to unraveling molecular mechanisms underlying repeated implantation failure and recurrent miscarriage. Mengying has published over ten influential research papers in high-impact journals such as Nature Communications and Cell Death and Differentiation. She utilizes advanced models, including transgenic mice, tissue-specific knockouts, organoids, and clinical samples, to identify novel therapeutic targets for improving pregnancy outcomes. Her funded projects and active participation in top national conferences reflect a strong academic presence and commitment to translational research. With a blend of innovation, rigorous methodology, and impactful results, Dr. Liu exemplifies the qualities of a leading scientist in reproductive immunology and maternal-fetal medicine.

Publication Profile: 

Scopus

✅ Strengths for the Award:

1. 📈 Strong Academic Background:

   • B.Sc. in Pharmaceutical Science (Jilin University)

   • Ph.D. in Chemical Biology (Xiamen University)

2. 🧬 Research Excellence:

   • Focused on clinically significant reproductive issues like recurrent miscarriage and implantation failure

   • Uses cutting-edge techniques: organoids, gene knockout models, and high-resolution molecular assays

3. 📚 Impressive Publication Record:

   • 11+ papers in high-impact journals: Nature Communications, PNAS, Cell Death & Differentiation, eLife

   • First/co-first author in several key studies

4. 💰 Secured Research Funding:

   • PI of two active provincial grants totaling 130,000 yuan

   • Demonstrates independent research capability and peer recognition

5. 🎤 Conference Engagement:

   • Delivered oral and poster presentations at national conferences

   • Consistent contributor to academic discourse in reproductive medicine

6. 🧩 Translational Value:

   • Work bridges clinical samples and mechanistic biology

   • Direct relevance to improving fertility treatment outcomes

⚙️ Areas for Improvement:

1. 🌍 International Collaboration:

   • While the research impact is nationally strong, expanding global academic networks or co-authorships with international labs would elevate visibility.

2. 🗣️ Broader Science Communication:

   • More active engagement in science outreach, media presence, or community health initiatives could enhance public recognition.

3. 📊 Leadership Roles:

   • Emerging leadership is evident, but increased involvement as a lead PI on larger consortiums or mentor roles in training programs would solidify standing.

🎓 Education:

Mengying Liu began her academic journey at Jilin University (2012–2016), earning a Bachelor’s degree in Pharmaceutical Science. During her undergraduate years, she cultivated a solid foundation in biochemistry, molecular biology, and pharmacology. Her academic curiosity and passion for translational research led her to pursue advanced studies at Xiamen University (2016–2022), where she obtained her Ph.D. in Chemical Biology. At XMU, she focused on the molecular regulation of female reproductive health, gaining deep expertise in epigenetics and gene expression regulation. Her doctoral work integrated bench-side science with clinically relevant questions, paving the way for her future as a researcher in maternal health. Both institutions are among China’s top-tier universities, where she received rigorous training and mentorship that refined her experimental, analytical, and collaborative skills—providing her with a strong educational backbone for her scientific career.

🧪 Experience:

Dr. Liu began her research career as an Assistant Researcher at Sir Run Run Shaw Hospital, Zhejiang University (2022–2025), where she worked on the molecular basis of embryo implantation and uterine development. She contributed to several major collaborative projects involving epigenetic regulation and reproductive pathology. In February 2025, she joined Hangzhou Women’s Hospital as an Assistant Researcher, further deepening her clinical research on female infertility and endometrial dysfunction. Her roles span across experimental design, clinical sample analysis, and manuscript preparation, showcasing her ability to bridge basic science and clinical application. With more than a decade of academic immersion, she has also been actively involved in national scientific conferences, gaining recognition as both a presenter and collaborator. Her experience working with multidisciplinary teams and her role in key research grants highlight her leadership potential and commitment to excellence in reproductive health research.

🔬 Research Focus:

Dr. Mengying Liu’s research centers on pregnancy-related diseases, specifically recurrent implantation failure and miscarriage. Her primary goal is to uncover epigenetic mechanisms, such as histone modifications (e.g., H3K4me3, H3K27me3), that impair endometrial receptivity and placental development. She employs a combination of clinical sample analysis, in vitro cell culture, 3D endometrial organoids, and genetically engineered mouse models to dissect the molecular pathways involved. A major part of her work involves understanding the role of Menin and the WNT signaling pathway in decidualization—a key process in embryo implantation. Through translational approaches, she aims to identify therapeutic targets for improving reproductive outcomes. Dr. Liu’s innovative integration of molecular biology with clinical relevance addresses an urgent medical need and positions her research at the intersection of epigenetics, immunology, and reproductive biology.

📚 Publications Top Notes:

1. 📘 Menin directs regionalized decidual transformation through epigenetically setting PTX3… – Nat Commun, 2022

2. 🧬 Endometrial stromal Menin supports endometrial receptivity via H3K4me3-mediated WNT regulation – Commun Biol, 2025

3. 🧫 Engraftment of self-renewing endometrial organoids regenerates glands in rats – Front Bioeng Biotechnol, 2024

4. 🧠 H3K27me3 dictates uterine epithelial remodeling essential for implantation – Cell Death Differ, 2024

5. 💉 miR-122-5p alleviates fibrosis in Asherman’s syndrome via TGF-β/SMAD inhibition – Reprod Biomed Online, 2023

6. 🧪 KRT18 regulates trophoblast cell migration and invasion during implantation – Reprod Biol Endocrinol, 2023

7. 🧬 SOX4 promotes PGR stability and FOXO1 expression in decidualization – eLife, 2022

8. 🧫 Ezh1/2 deficiency delays H3K27me restoration, impairing epiblast development – Development, 2022

9. 🧬 Shp2 in uterine stroma governs embryo implantation via multiple pathways – PLoS Genet, 2022

10. 🧠 Epigenetic control of embryo-uterine crosstalk at peri-implantation – Cell Mol Life Sci, 2019

11. 🧬 Blastocyst activation triggers transcriptome changes for implantation – PNAS, 2019

🧾 Conclusion:

Dr. Mengying Liu demonstrates all the qualities of a high-impact early-career researcher—deep scientific knowledge, methodological rigor, strong publication metrics, and clinical relevance. Her work addresses urgent medical challenges in reproductive health and leverages advanced epigenetic tools, contributing significantly to maternal-fetal medicine.